Genes & LADA

[skb]

the team found that the strongest genetic signals in LADA were mainly shared with established variants known to be linked to T1D. However, the researchers discovered a novel locus with genome-wide significance near the gene PFKFB3. This gene codes for a protein that regulates both insulin signaling and glycolisis, the chemical reaction that yields energy from glucose. "This finding points to how variants at PFKFB3 may help to drive LADA,"

http://care.diabetesjournals.org/content/early/2018/09/18/dc18-1032

[foxl]

I did 23andMe and then Promethease, which provides an in-depth analysis of genetic risks.  I found that I have melatonin receptor genes, in addition to the major genes contributing to Type 1, and *'s, in the Major Histocompatibility Complex on chromosome 6.  Looks like a terrific combination for LADA.  In my case, there are so many other contributing factors, including viral infections,high-carb (starch) diet, Celiac genes ... ugh! 

[walkerwally1]

Hi foxyl, hope you are doing OK.  Good to hear from you.

[bigskygal]

Hi foxl! Glad to see you posting!! Hope all is well with you.