How Metformin works

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Millions of people take metformin, a Type 2 diabetes medication that lowers blood sugar. The "wonder drug" has also been shown to slow cancer growth, improve COVID outcomes and reduce inflammation. But until now, scientists have been unable to determine how, exactly, the drug works.   

A new Northwestern Medicine study has provided direct evidence in mice that the drug reversibly cuts the cell's energy supply by interfering with mitochondria, often referred to as the cell's "powerhouse," to lower glucose levels.

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