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Groundbreaking Antidiabetic Compound Unveiled

Started by skb, December 15, 2024, 12:42:29 AM

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skb

QuoteKumamoto University scientists have unveiled a novel compound, HPH-15, with dual effects of reducing blood glucose levels and combating fat accumulation, marking a significant leap in diabetes treatment innovation.

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No meds since June 2011
Controlled by Diet & Exercise
Member of 5% A1c Club

Blog : Metabolically Challenged

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skb

The post title or the headline isn't mine. I just copied it from the site.
Google wasn't helpful in giving me any information on what is this compound HPH-15, so I turned to Chat-GPT and I learnt that the compound was developed to fight aggressive cancers. Here's what I got.

QuoteHPH-15 refers to 3-((1H-pyrrolo[3,2-b]pyridin-1-yl)methyl)aniline, a compound primarily recognized in medicinal chemistry. It has gained attention as a potent and selective inhibitor of the enzyme NQO1 (NAD(P)H:quinone oxidoreductase 1).

Key Features:
Target:
NQO1 is an enzyme involved in cellular redox regulation and plays a significant role in cancer biology, as it is often overexpressed in tumor cells.
Mechanism of Action: HPH-15 selectively inhibits NQO1, potentially disrupting cellular antioxidant defense mechanisms and inducing cell death in cancer cells.
Applications:
Cancer Research:
Investigated for its therapeutic potential in cancers with high NQO1 expression.
Research Tool: Used to study the role of NQO1 in cellular processes.
Structure: The compound consists of a pyrrolopyridine core linked to an aniline moiety via a methyl group.
No meds since June 2011
Controlled by Diet & Exercise
Member of 5% A1c Club

Blog : Metabolically Challenged

You Tube Channel HEALTHY WEIGH